Our Medical Specialties Doctors
Hemen Arayın

Expertise & Areas of interest

  • Anterior segment and cornea
  • Cataract surgery
  • Glaucoma
  • Glaucoma surgery
  • Medical retina
  • Pediatric ophthalmology
  • Diseases of the Uvea and Behçet’s disease
  • Neuroophthalmology
  • Aviation medicine
  • High altitude ophthalmology


Prof. M. Sarper Karaküçük completed his medical education at Ankara University Medical School, part of his internship at St. George’s Hospital Medical School, London, and his specialty training in Ophthalmology at Erciyes University Ophthalmology Department. He became an Associate Professor in 1999 and Professor in 2005. Prof. Karaküçük has been serving as an Ophthalmologist and the director of the Ophthalmology clinic at Anadolu Medical Center since 2015. 

He also holds the degree of AME, Aviation Medical Officer which authorizes him to examine pilots as well as other aviation personnel, and also is the director of the Aviation Medicine Center at the hospital. 



Ankara University Medical School, Ankara 1984 

Specialty education 

Erciyes University Ophthalmology Department, Kayseri 1993

Sub-specialty training 

AME (Aviation Medical Examiner: authorized medical examiner for pilots and other aviation personnel),  Eskişehir Aviation Medicine Research and Training Center, and Gülhane Military Medicine Academy, Aerospace Medicine Department, 2012 

Associate Professor 

Erciyes University Ophthalmology Department, Kayseri 1999


Erciyes University Ophthalmology Department, Kayseri 2015

Institutional Memberships

Turkish Ophthalmology Society 

Turkish Ophthalmology Society Glaucoma Unit 

Turkish Ophthalmology Society Medicolegal Ophthalmology Unit 

Turkish Aviation Medicine Society 

Turkish Sleep Medicine Society 

European Union - European Commission, 6th and 7th Framework International Scientific
Projects; Member and rapporteur of the  Evaluation Committee, Brussels, Belgium

European Association for Vision and Eye Research (EVER), Belgium

Aerospace Medical Association (ASMA), USA

International Society of Mountain Medicine (ISMM)

American Alpine Club (AAC)

Wilderness Medical Society (WMS)


International Publications

Arda H, Mirza GE, Polat OA, Karakucuk S, Oner A, Gumus K. Effects of chronic smoking on color vision in young subjects. Int J Ophthalmol. 2015 Feb 18;8(1):77-80.  
Gumus K, Karakucuk S, Mirza GE, Akgun H, Arda H, Oner AO. Overexpression of vascular endothelial growth factor receptor 2 in pterygia may have a predictive value for a higher postoperative recurrence rate. Br J Ophthalmol 2013 Feb 1 (E pub ahead of print).
Arda H, Birer S, Aksu M, Ismailogullari S, Karakucuk S, Mirza E, Gumus K, Oner A. Obstructive sleep apnoea prevalence in non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2012; 97(2): 206-209 
Karakucuk S, Mujdeci M, Baskol G, Arda H, Gumus K, Oner A. Changes in central corneal thickness, intraocular pressure, and oxidation/antioxidation parameters at high altitude. Aviat Space Environ Med. 2012 Nov;83(11):1044-8.
Per H, Canpolat M, Gümüş H, Poyrazoğlu HG, Yıkılmaz A, Karakucuk S, Doğan H, Kumandaş S. Clinical spectrum of the pseudotumor cerebri in children: Etiological, clinical features, treatment and prognosis. Brain Dev. 2012 Sep 13. doi:pii: S0387-7604(12)00217-3. 10.1016/j.braindev.2012.08.008. [Epub ahead of print]
Arda H, Mirza E, Gumus K, Oner A, Karakucuk S, Sırakaya E.
Orbital Apex Syndrome in Herpes Zoster Ophthalmicus. Case Rep Ophthalmol Med. 2012;2012:854503. Epub 2012 Jul 9.
Gumus K, Topaktas D, Göktaş A, Karakucuk S, Oner A, Mirza GE.
The Change in Ocular Higher-Order Aberrations After Pterygium Excision With Conjunctival Autograft: A 1-Year Prospective Clinical Trial. Cornea. 2012; Dec;31(12):1428-31.
Goktas A, Gumus K, Mirza GE, Crockett C, Karakucuk S, Dwight Cavanagh H. Corneal Endothelial Characteristics and Central Corneal Thickness in a Population of Turkish Cataract Patients. Eye Contact Lens. 2012  May;38(3):142-5
Oner A, Gumus K, Arda H, Yuce Y, Karakucuk S, Mirza E. Pattern electroretinographic results after photodynamic therapy alone and photodynamic therapy in combination with intravitreal bevacizumab for choroidal neovascularization in age-related macular degeneration.             Doc Ophthalmol. 2009 Aug;119(1):37-42.
Arda H, Oner A, Gumus K, Karakucuk S, Mirza E. The results of electrophysiological tests in unilateral extensive peripapillary myelinated nerve fibers: report of three cases. Doc Ophthalmol. 2009  119 (3): 225-228
Gumus K, Yurci A, Mirza E, Arda H, Oner A, Topaktas D, Karakucuk S. Evaluation of Ocular Surface Damage and Dry Eye Status in Chronic Hepatitis C at Different Stages of Hepatic Fibrosis. Cornea. 2009 28 (9): 997-1002.
Gumus K, Mirza GE, Cavanagh HD, Karakucuk S. Topical cyclosporine A as a steroid-sparing agent in steroid-dependent idiopathic ocular myositis with scleritis: a case report and review of the literature. Eye Contact Lens. 2009 Sep;35(5):275-8.
Oner A, Gumus K, Arda H, Karakucuk S, Mirza E. Pattern electroretinographic recordings in eyes with myopia. Eye Contact Lens. 2009 Sep;35(5):238-41.
Baskol G, Gumus K, Oner A, Arda H, Karakucuk S. The role of advanced oxidation protein products and total thiols in diabetic retinopathy. Eur J Ophthalmol 18(5):792-798; 2008. 
Mirza E, Gumus K, Evereklioglu C, Arda H, Oner A, Canoz O, Karakucuk S. Invasive squamous cell carcinoma of the conjunctiva first misdiagnosed as a pterygium: a clinicopathologic case report. Eye Contact Lens 34(3):188-190; 2008. 
Karakucuk S, Goktas S, Aksu M, Erdogan N, Demirci S, Oner A, Arda H, Gumus K. Ocular blood flow in patients with obstructive sleep apnea syndrome (OSAS).
Graefes Arch Clin Exp Ophthalmol. 2008 Jan;246(1):129-34. 
Gumus K, Karakucuk S, Mirza E.
Corneal injury from a metallic foreign body: an occupational hazard.
Eye Contact Lens. 2007 Sep;33(5):259-60.
Arda H, Oner A, Mutlu S, Kose Z, Gumus K, Karakucuk S, Mirza E. 
Multifocal electroretinogram for assessing sun damage following the solar eclipse of 29 March 2006: multifocal electroretinography in solar maculopathy. Doc Ophthalmol. 2007 May;114(3):159-62.  
Karakucuk S, Soyuer S, Oner AO, Soyuer I, Yaray K, Mirza E, Baskol G, Akin A. Experimental posterior perforating ocular injury in rabbit eyes: effects of radiotherapy with or without intravitreal cyclosporin on vitreous proliferation. Ophthalmologica. 2006;220(1):6-11.
Baskol G, Karakucuk S, Oner AO, Baskol M, Kocer D, Mirza E, Saraymen R, Ustdal M. Serum paraoxonase 1 activity and lipid peroxidation levels in patients with age-related macular degeneration.
Ophthalmologica. 2006;220(1):12-6.
Oner A, Karakucuk S, Serin S. Nasolacrimal endometriosis. A case report.
Ophthalmic Res. 2006;38(5):313-4.  
Oner A, Kekec Z, Karakucuk S, Ikizceli I, Sozuer EM. Ocular trauma in Turkey: a 2-year prospective study.
Adv Ther. 2006 Mar-Apr;23(2):274-83.  
Oner A, Karakucuk S, Mirza E, Erkilic K. The changes of pattern electroretinography at the early stage of photodynamic therapy.
Doc Ophthalmol. 2005 Sep;111(2):107-12.  
Oner A, Karakucuk S, Mirza E, Erkilic K. Electrooculography after photodynamic therapy.
Doc Ophthalmol. 2005 Sep;111(2):83-6.  
Karakucuk S, Başkol G, Öner AO, Başkol M, Mirza E, Üstdal M. Serum paraoxonase activity is decreased in the active stage of Behçet’s disease.  
Br J Ophthalmol 88: 1256-1258; 2004.
Karakucuk S, Öner AÖ, Göktaş S, Sıkı E, Köse Ö. Color vision changes in young subjects acutely exposed to 3000 m altitude. Aviat Space Environ Med 75 :364-366; 2004.
Öner A, Ferahbaş A, Karakucuk S, Utaş S, Karaman B, Kutlugün C, Somdas M, Mirza E. Ocular side effects associated with systemic isotretinoin. Journal of Toxicology - Cutaneous and Ocular Toxicology 23: 189-195; 2004.
Karakucuk S, Mirza GE, Karaküçük İ, Akal A, Er M. Nitric Oxide levels in Tears of Patients with mild forms of Papillary Conjunctivitis Induced by Rigid Gas Permeable Contact Lenses. The CLAO Journal 28: 5-8; 2002. 
Mirza GE, Karakucuk S, Er M, Güngörmüş N, Karaküçük İ, Saraymen R. Tear nitrite and nitrate levels as nitric oxide end-products in patients with Behçet’s Disease and non-Behçet’s uveitis. Ophthalmic Research 33: 48-51; 2001.
Karakucuk S, Mirza GE. 25 year old woman with loss of vision of the left eye. Digital Journal of Ophthalmology, 7: 2001.

Karakucuk S, Mirza GE, Sümerkan B, Okten T. Intravitreal trovafloxacin against  experimental Staphylococcus epidermidis endophthalmitis. Ophthalmic Research  32: 30-40; 2000.
Karakucuk S, Mirza GE. Ophthalmological effects of high altitude. Ophthalmic Research 32: 30-40; 2000.
Mirza GE, Karakucuk S, Temel E. Comparison of the effects of 0.5% timolol maleate, 2% carteolol hydrochloride and 0.3% metipranolol on intraocular pressure and perimetry findings and evaluation of their ocular and systemic side-effects. Journal of Glaucoma 9:45-50; 2000.
Watts P, Karakucuk S, McAllister J. Measurement of the retinal nerve fiber layer thickness with a nerve fiber analyzer in normal subjects. Lasers and Light  7: 79-84; 1996.
Karakucuk S, Mirza GE, Ekinciler ÖF, Saraymen R, Karaküçük İ, Üstdal M. Selenium concentrations in serum, lens and aqueous humour of patients with senile cataract. Acta Ophthalmologica Scandinavica 73: 329-332; 1995.
Mirza GE, Karakucuk S, Doğanay M, Çağlayangil A. Postoperative endophthalmitis caused by an enterobacter species. The Journal of Hospital Infection 26: 167-171; 1994.
Mirza GE, Karakucuk S, Doğan H, Erkılıç K. Filtering surgery with mitomycin-C in uncomplicated (primary open angle) glaucoma.  Acta Ophthalmologica 72:155-161; 1994.
Mirza GE, Ekinciler ÖF, Karakucuk S. Diagnosis and management of a biorbital pencil injury: Case Report.   Acta Ophthalmologica 71: 266-269; 1993.
Mirza GE, Karakucuk S:  A rare corneal injury caused by molten lead: Case report . Acta Ophthalmologica 71. 573-574; 1993.
Akdemir H, Paşaoğlu A, Ekinciler ÖF, Selçuklu A, Karakucuk S, Öktem İS. Unilateral naso-orbital meningocele and bilateral congenital fistulae of the lacrimal passages. Acta Ophthalmologica 69:680-683; 1991.

National Publications

Öner A, Kılıç R, Polat OA, Arda H, Karaküçük S, Mirza E. Pars plana vitrectomy in intra-ocular lens nucleus dislocated into the vitreus during cataract surgery and due to trauma. Cumhuriyet Medical Journal 2013; 35: 345-349
Göktaş A, Gümüş K, Arda H, Topaktaş D, Öner A, Karaküçük S, Mirza E. Acute Dacryocystitis after Non-complicated Pterygium Surgery. Turk J Ophthalmol 2012; 42: 78-80)
Kılıç R, Öner A, Arda H, Gümüş K, Karaküçük S, Mirza E. Our clinical approach to and results in cases with endophthalmia.   Retina-Vitreus 2012; 1:31-34
Karaküçük S, Yüce Y, Liman N, Ulusal H, Öner A, Gümüş K,  Mirza E, Müjdeci M. Topikal The Effects of Antiglaucomatous Agents on Ganglion Cell Apoptosis. Erciyes Tıp Dergisi (Erciyes Medical Journal) 2009;31(4):310-317.
Gümüş K, Topaktaş D, Arda H, Öner A, Evereklioğlu C, Mirza E, Karaküçük S.  Clinical and Demographic Characteristics of Perforating Eye Injuries in Childhood. Turkiye Klinikleri J Ophthalmol 2009;18(1):7-12
Mirza GE, Öner A, Karaküçük S, Patıroğlu T, Arda H. Vogt Koyanagi Harada Syndrome: Presentation of two cases. Retina-Vitreus 215: 137-140; 2007. 
Öner A, Özkırış A, Karaküçük S, Mirza E, Erkılıç K. Our 18-month results in photodynamic treatment. Erciyes Medical Journal 2007;29(1):35-39.
Mazıcıoğlu M, Karaküçük S, Öner A, Ulusal H, Mirza GE. The effect of high altitude on the vision of mountaineers climbing Mount Ararat.  
Erciyes Medical Journal 2006;28(3):134-137
Öner A, Ferahbaş A, Karaküçük S, Utaş S, Karaman B, Mirza E. The effect of systemic isotretinoin therapy on lacrimal apparatus. 
MN-Ophtalmology Journal 2005;12(1):63-65.
Öner A, Özkırış A, Güneş T, Karaküçük S, Erkılıç K, Çetin N. Premature retinoplasty:  Our 2-year results. Erciyes Medical Journal 27: 104-109; 2005.
Öner A, Karaküçük S, Mirza GE, Ekmekçioğlu O, Baykal E.
Ocular effects of three-month regular use of sildenafil 
Turkish Journal of Ophthalmology 2004;34(4):287-290
Başkol G, Karaküçük S, Öner A, Mirza GE, Koçer D. Serum MDA and AOPP levels in age related macular degeneration. Erciyes Medical Journal 26: 7-11; 2004.
Öner A, Karaküçük S, Mirza GE, Ekmekçioğlu O, Baykal E. The ocular effects of single dose sildenafil. Turkish Journal of Ophthalmology 33:767-770; 2003.
Karaküçük S. TUBITAK symposium on “Scientific Publications in the 21st Century: Aims and Approaches”. Erciyes Medical Journal 23: 190-193; 2001.
Karaküçük S, Karaküçük İ, Mirza GE. Interleukin-6 levels in the sera of patients with diabetic retinopathy. Erciyes Medical Journal 21: 52-59; 1999. 
Karaküçük S, Mirza GE, Karaküçük İ, Sümerkan B, Okten T, Saraymen R, Haytoğlu T. The effect of intravitreal trovafloxacin on vitreus nitric oxide levels in experimental Staphylococcus epidermidis endophtalmy. Erciyes Medical Journal 21: 35-41; 1999.
Durukan A, Karaküçük S, Mirza GE. Bilateral total ophthalmology caused by a large cystic craniopharyngioma.  Erciyes Medical Journal 21: 130; 1999.
Mirza GE, Karaküçük S, Doğan H, Erkılıç K. Comparison of two different concentrations of mitomycin-C in the surgical treatment of  primary open angle glaucoma. Erciyes Tıp Dergisi  21: 132-138; 1999.
Akal A, Çaksen H, Doğan H, Karaküçük S. Intraorbital foreign object.   Yeni Tıp Dergisi 15: 337-339; 1998.
Aksu M, Ersoy AÖ, Karaküçük S, Doğan H. A case of atypical Cogan Syndrome and review of literature. Turkish Journal of Medical Sciences  28:705-707; 1998.
Doğan H, Karaküçük S. A new technique for trabecular block excision during standart trabeculectomy. Erciyes Medical Journal 18:  36-37; 1996.
Doğan H, Karaküçük S. New mucosa separators in Toti's dacryocystorhinostomy. European Journal of Plastic Surgery 19:166; 1996.
Karaküçük S, Mirza GE, Ekinciler ÖF, Saraymen R, Karaküçük İ, Üstdal M. Zinc and copper concentrations in serum, lens and aqueous humor in patients with senile cataract.  Türkiye Klinikleri Ophthalmology Journal  4: 116-121; 1995.
Karaküçük S, Mirza GE, Çağıl N, Durukan A. Terrien's marginal degeneration of the cornea: A case report. Erciyes Medical Journal  15: 102-104; 1993.
Doğan H, Uysal E, Güler B, Bozkır M, Ekinciler ÖF, Karaküçük S. Keratometric changes occurring after trabeculectomy.  Turkish Journal of Ophthalmology  22:  552-556; 1993.
Ekinciler ÖF, Doğan H, Tatlışen N, Karaküçük S. The problem of non-compliance with medical treatment in glaucoma patients. Erciyes Medical Journal 14: 215-221; 1992.
Ersoy Ö, Boyacı A, Doğan H, Günal C, Madenoğlu H, Karaküçük S. Comparison of droperidol, lidocaine and bupivacaine administration to ocular muscles to prevent vomiting after strabismus surgery.  Erciyes Medical Journal 14: 103-108; 1992.
Karaküçük S. Monoclonal antibodies and their use in ophthalmology.   Yeni Tıp Dergisi 4: 65-68; 1987.
Karaküçük S: Behçet Syndrome.Yeni Tıp Dergisi (Ankara), 3 (6): 54-56, 1986.
International book chapter: 
Karakucuk S: Effects of high altitude related oxidative stress on intraocular pressure and central corneal thickness: a research model for the etiology of glaucoma. In: Glaucoma (2012). In Tech publishers,ISBN:978-953-308-90-3

National book chapters:

Karaküçük S. Examination methods in glaucoma. ‘Basic Eye Diseases” book, Güneş kitabevi, Ankara, 2011. Editor: Aydın P. 
Karaküçük  S.  Analysis of Glaucoma Progression. ‘Visual Field” book, Dünya Kitabevi, Ankara; 2005  Editor: Aydın P.
Karaküçük  S. Ankylosing  Spondylitis Uveitis. In: ‘Uveitis’ Handbook. Editors: Aydın P, Akduman L. Güneş Kitabevi; Ankara,  2004
Karaküçük  S.   Iris (Ch 12). In:  Ocular differential diagnosis. Roy FH. Aydın P (ed). 7th edition. Güneş Kitabevi Ankara, 2004. (Lippincott William Wilkins). 
Conferences and presentations at international congresses: 
Karakucuk S, et al. Retinal changes in young subjects after an acute unacclimatized short exposure to high altitude.  ASMA (Aerospace Medical Association) 85th Scientific Meeting, 11-15 May 2014, San Diego, California, USA
Karakucuk S. Anterior segment and oxidative/antioxidative system changes after an acute non acclimatized high altitude exposure. IOSS (International Ocular Surface Society) meeting, Seattle, USA, 4 Mayıs 2013   
Karakucuk S, Polat B, Mirza E, Arda H, Gumus K, Oner A. Contrast Sensitivity, Electroretinography and Optical Coherence Tomography Changes in Young Subjects After an Acute Unacclimatized Short Exposure to High Altitude) ARVO (Association for Research in Vision and Ophthalmology) meeting, Seattle, 4-8 Mayıs 2013, USA
Karakucuk S, Polat B, Mirza E, Arda H, Gumus K, Oner A. Hypoxia related changes in photoreceptor functions in young subjects acutely exposed to high altitude). Hypoxia Congress, 18th Meeting, 26 Şubat-2 Mart 2013, Lake Louise, Calgary, Canada
Karakucuk S, Öncü M, Gümüs K, Arda H, Soyuer I, Baskol G, Baskol M, Mirza E, Oner A. Ocular surface disorders in patients with inflammatory bowel diseases) The 4th World Congress on Controversies in Ophthalmology (COPHy) Budapest, Hungary, 4-7 Nisan, 2013 
Karaküçük S, Müjdeci M, Başkol G. Response of the human eye against oxidative stress at high altitudes.   EVER, European Association for Vision and Eye Research, 8 October 2010, Crete, Greece.

Karaküçük S, Yuce Y, Ulusal H, Oner AO, Gumus K, Mirza E, Liman N. Effects of antiglaucomatous topical medications on retinal ganglion cell apoptosis in an experimental rat model. 6. th International Glaucoma Symposium, 28 March 2007, Athens, Greece
Karaküçük S, Goktas S, Aksu M, Demirci S, Mirza E, Oner A, Ulusal H, Erdogan N. Glaucoma prevalance and ocular blood flow in patients with obstructive sleep apnea. Oxford Ophthalmological Congress, 3-6 July 2005, Oxford, UK
Öner A, Baskol G, Karaküçük S, Özkırış A, Mirza E. Serum paraoxanase activity is decreased in Type 2 Diabetic Patients with retinopathy. Mediterranean Retina 2004, June 25-27 2004, Antalya-Turkey
Karaküçük S, Mazicioğlu M, Öner A. Effects of High Altitude on Color Vision of Middle Aged Climbers During an Expedition to Mt. Ağrı (Ararat).  17th World Conference of Family Doctors, 13-17 October, 2004, Orlando, USA.
Öner A, Kekec Z, Karaküçük S, İkizceli İ, Sözüer EM. Eye trauma in Turkey. The Second Mediterranean Emergency Medicine Congress. Barcelona, Spain. 13-17 September, 2003. 
Watts P, Karaküçük S, McAllister J: Measurement of the retinal nerve fiber layer thickness with a nerve fibre analyser in normal subjects.   1995 Annual Congress, The Royal College of Ophthalmologists Meeting, Birmingham, UK.  

Course Participation

Trainee and trainer for many congresses of the Turkish Ophthalmology Society 

Aviation Medicine Course

Training the trainers  Course

Handling and doing research on Experimental Animals: A practical course 

Scientific studies at various eye clinics in Canada, UK, Austria and Italy. 

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